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Images can be stacked/scrolled when the "Stack Scroll" button is selected by left-clicking and dragging the mouse up or down. If you are using a wheel mouse, the wheel function will also scroll the images. There is also a blue scroll bar on the right side that can be dragged to scroll the images.
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"Crosshairs" tool can be used to determine the position of mouse location on other simultaneously displayed images. Left-click on the image and drag the mouse to use the tool in a layout with the related images.
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Users can change the default preferences such as layout, keyboard shortcuts, etc. based based on their needs. The user preferences are persisted even after the session is closed. "Preferences" button is used to show the user preferences dialog.
For a better understanding of user preferences, refer to User Preferences.